Negative regulation of the vascular smooth muscle alpha-actin gene in fibroblasts and myoblasts: disruption of enhancer function by sequence-specific single-stranded-DNA-binding proteins.

doi:10.1128/MCB.15.5.2429

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Article

Negative regulation of the vascular smooth muscle alpha-actin gene in fibroblasts and myoblasts: disruption of enhancer function by sequence-specific single-stranded-DNA-binding proteins.

Molecular and cellular biology - 1 May 1995

Sun S, Stoflet E S, Cogan J G, Strauch A R, Getz M J

Abstract excerpt

Transcriptional activation and repression of the vascular smooth muscle (VSM) alpha-actin gene in myoblasts and fibroblasts is mediated, in part, by positive and negative elements contained within an approximately 30-bp polypurine-polypyrimidine tract. This region contains binding sites for an es...

Topics

Actins
Animals
Base Sequence
Binding Sites
Cell Line
Conserved Sequence
DNA, Single-Stranded
DNA-Binding Proteins
Down-Regulation
Enhancer Elements, Genetic
Fibroblasts

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Molecular Sequence Data

Muscle, Smooth, Vascular

Mutation

Promoter Regions, Genetic

TEA Domain Transcription Factors

Transcription Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 7739527
DOI: 10.1128/MCB.15.5.2429
PMCID: PMC230472

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7739527-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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