Article
IL-10 high producing genotype predisposes HIV infected individuals to TB infection.
Human immunology - 1 Jun 2012
Ramaseri Sunder Sharada, Hanumanth Surekha Rani, Nagaraju Raghavendar Thyagaraja, Venkata Sanjeev Kumar Neela, Suryadevara Naveen Chandra, Pydi Satya Sudheer, Gaddam Sumanlatha, Jonnalagada Subbanna, Valluri Vijaya Lakshmi
Abstract excerpt
Interleukin (IL-10), an anti-inflammatory cytokine, is known to have dual effect on the host immune system. One of these roles is that it provides an effective autoregulatory mechanism which protects the host from excessive inflammation and tissue damage which is in part initiated by the Th1 driven pro-inflammatory immune responses during infections (such as TB, HIV and malaria). However, though beneficial, this...
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