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Article

Genetic association between NLRP3 variants and Crohn's disease does not replicate in a large UK panel.

Inflammatory bowel diseases - 1 Jun 2011

Lewis Gregory J, Massey Dunecan C O, Zhang Hu, Bredin Francesca, Tremelling Mark, Lee James C, Berzuini Carlo, Parkes Miles

Abstract excerpt

BACKGROUND: NLRP3 (formerly known as CIAS1 or NALP3) encodes a key component of the inflammasome and is a strong candidate gene for Crohn's disease (CD) susceptibility. A recent study reported significant and internally replicated association between CD and six single nucleotide polymorphisms (SN...

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Source

Identifiers

PMID: 21560198
DOI: 10.1002/ibd.21499

Genes

NLRP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21560198-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Genetic association between NLRP3 variants and Crohn's disease does not replicate in a large UK panel.PMID 21560198Read ↗

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