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Article

Association of a functional variant in the Wnt co-receptor LRP6 with early onset ileal Crohn's disease.

PLoS genetics - 1 Jan 2012

Koslowski Maureen J, Teltschik Zora, Beisner Julia, Schaeffeler Elke, Wang Guoxing, Kübler Irmgard, Gersemann Michael, Cooney Rachel, Jewell Derek, Reinisch Walter, Vermeire Séverine, Rutgeerts Paul, Schwab Matthias, Stange Eduard F, Wehkamp Jan

Abstract excerpt

Ileal Crohn's Disease (CD), a chronic small intestinal inflammatory disorder, is characterized by reduced levels of the antimicrobial peptides DEFA5 (HD-5) and DEFA6 (HD-6). Both of these α-defensins are exclusively produced in Paneth cells (PCs) at small intestinal crypt bases. Different ileal CD-associated genes including NOD2, ATG16L1, and recently the β-catenin-dependant Wnt transcription factor TCF7L2 have...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Low Density Lipoprotein Receptor-Related Protein-6

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Source

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Identifiers

PMID: 22393312
DOI: 10.1371/journal.pgen.1002523
PMCID: PMC3285585

Genes

LRP6
DEFA5
DEFA6
NOD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Association of a functional variant in the Wnt co-receptor LRP6 with early onset ileal Crohn's disease.PMID 22393312Read ↗

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