Article
Coordinately regulated alternative splicing of genes involved in cholesterol biosynthesis and uptake.
PloS one - 29 Apr 2011
Medina Marisa Wong, Gao Feng, Naidoo Devesh, Rudel Lawrence L, Temel Ryan E, McDaniel Allison L, Marshall Stephanie M, Krauss Ronald M
Abstract excerpt
Genes involved in cholesterol biosynthesis and uptake are transcriptionally regulated in response to cellular sterol content in a coordinated manner. A number of these genes, including 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) and LDL receptor (LDLR), undergo alternative splicing, resulting in reductions of enzyme or protein activity. Here we demonstrate that cellular sterol depletion suppresses,...
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