Article
Genetic association between helpless trait and depression-related phenotypes: evidence from crossbreeding studies with H/Rouen and NH/Rouen mice.
The international journal of neuropsychopharmacology - 1 Apr 2012
El Yacoubi Malika, Popa Daniela, Martin Benoît, Zimmer Luc, Hamon Michel, Adrien Joëlle, Vaugeois Jean-Marie
Abstract excerpt
Genetic factors are believed to be involved in the aetiology of unipolar depressive disorders. We have previously described a model built up by selective breeding of mice with different responses in the tail suspension test, a screening test for potential antidepressants. In this model, helpless H/Rouen mice are essentially immobile in this test, as well as in the Porsolt forced-swim test, whereas non-helpless...
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