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Article

Mesenchymal MACF1 Facilitates SMAD7 Nuclear Translocation to Drive Bone Formation

4 Mar 2020

Abstract excerpt

Microtubule actin crosslinking factor 1 (MACF1) is a large crosslinker that contributes to cell integrity and cell differentiation. Recent studies show that MACF1 is involved in multiple cellular functions such as neuron development and epidermal migration, and is the molecular basis for many degenerative diseases. MACF1 is highly abundant in bones, especially in mesenchymal stem cells; however, its regulatory...

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PMID: 32143362
DOI: 10.3390/cells9030616

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