Article
Mutations in gp41 are correlated with coreceptor tropism but do not improve prediction methods substantially.
Antiviral therapy - 1 Jan 2011
Thielen Alexander, Lengauer Thomas, Swenson Luke C, Dong Winnie W Y, McGovern Rachel A, Lewis Marilyn, James Ian, Heera Jayvant, Valdez Hernan, Harrigan P Richard
Abstract excerpt
BACKGROUND: The main determinants of HIV-1 coreceptor usage are located in the V3-loop of gp120, although mutations in V2 and gp41 are also known. Incorporation of V2 is known to improve prediction algorithms; however, this has not been confirmed for gp41 mutations. METHODS: Samples with V3 and gp41 genotypes and Trofile assay (Monogram Biosciences, South San Francisco, CA, USA) results were taken from the HOMER...
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