Article
Allele-dependent interaction of LRRK2 and NOD2 in leprosy.
PLoS pathogens - 1 Mar 2023
Dallmann-Sauer Monica, Xu Yong Zhong, da Costa Ana Lúcia França, Tao Shao, Gomes Tiago Araujo, Prata Rhana Berto da Silva, Correa-Macedo Wilian, Manry Jérémy, Alcaïs Alexandre, Abel Laurent, Cobat Aurélie, Fava Vinicius M, Pinheiro Roberta Olmo, Lara Flavio Alves, Probst Christian M, Mira Marcelo T, Schurr Erwin
Abstract excerpt
Leprosy, caused by Mycobacterium leprae, rarely affects children younger than 5 years. Here, we studied a multiplex leprosy family that included monozygotic twins aged 22 months suffering from paucibacillary leprosy. Whole genome sequencing identified three amino acid mutations previously associated with Crohn's disease and Parkinson's disease as candidate variants for early onset leprosy: LRRK2 N551K, R1398H and...
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