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Article

Rpe65 is the retinoid isomerase in bovine retinal pigment epithelium.

Cell - 12 Aug 2005

Jin Minghao, Li Songhua, Moghrabi Walid N, Sun Hui, Travis Gabriel H

Abstract excerpt

The first event in light perception is absorption of a photon by an opsin pigment, which induces isomerization of its 11-cis-retinaldehyde chromophore. Restoration of light sensitivity to the bleached opsin requires chemical regeneration of 11-cis-retinaldehyde through an enzymatic pathway called...

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Share to Catalysis
Share to cis-trans-Isomerases
Share to DNA, Complementary

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Eye Proteins

Share to Gene Expression Regulation, Enzymologic

Share to Molecular Structure

Share to Optic Atrophy, Hereditary, Leber

Share to Pigment Epithelium of Eye

Source

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Identifiers

PMID: 16096063
DOI: 10.1016/j.cell.2005.06.042
PMCID: PMC2748856

Genes

RPE65

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-16096063-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

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Negative charge of the glutamic acid 417 residue is crucial for isomerohydrolase activity of RPE65.Semantic proximity Read ↗

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