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Genome-wide copy-number variation analysis identifies common genetic variants at 20p13 associated with aggressiveness of prostate cancer.

Carcinogenesis - 1 Jul 2011

Jin Guangfu, Sun Jishan, Liu Wennuan, Zhang Zheng, Chu Lisa W, Kim Seong-Tae, Sun Jielin, Feng Junjie, Duggan David, Carpten John D, Wiklund Fredrik, Grönberg Henrik, Isaacs William B, Zheng S Lilly, Xu Jianfeng

Abstract excerpt

The genetic determinants for aggressiveness of prostate cancer (PCa) are poorly understood. Copy-number variations (CNVs) are one of the major sources for genetic diversity and critically modulate cellular biology and human diseases. We hypothesized that CNVs may be associated with PCa aggressiveness. To test this hypothesis, we conducted a genome-wide common CNVs analysis in 448 aggressive and 500 nonaggressive...

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PMID: 21551127
DOI: 10.1093/carcin/bgr082
PMCID: PMC3128563

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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