Article
Identification of functionally active, low frequency copy number variants at 15q21.3 and 12q21.31 associated with prostate cancer risk.
Proceedings of the National Academy of Sciences of the United States of America - 24 Apr 2012
Demichelis Francesca, Setlur Sunita R, Banerjee Samprit, Chakravarty Dimple, Chen Jin Yun Helen, Chen Chen X, Huang Julie, Beltran Himisha, Oldridge Derek A, Kitabayashi Naoki, Stenzel Birgit, Schaefer Georg, Horninger Wolfgang, Bektic Jasmin, Chinnaiyan Arul M, Goldenberg Sagit, Siddiqui Javed, Regan Meredith M, Kearney Michale, Soong T David, Rickman David S, Elemento Olivier, Wei John T, Scherr Douglas S, Sanda Martin A, Bartsch Georg, Lee Charles, Klocker Helmut, Rubin Mark A
Abstract excerpt
Copy number variants (CNVs) are a recently recognized class of human germ line polymorphisms and are associated with a variety of human diseases, including cancer. Because of the strong genetic influence on prostate cancer, we sought to identify functionally active CNVs associated with susceptibility of this cancer type. We queried low-frequency biallelic CNVs from 1,903 men of Caucasian origin enrolled in the...
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