Article
Association of a germ-line copy number variation at 2p24.3 and risk for aggressive prostate cancer.
Cancer research - 15 Mar 2009
Liu Wennuan, Sun Jishan, Li Ge, Zhu Yi, Zhang Scott, Kim Seong-Tae, Sun Jielin, Wiklund Fredrik, Wiley Kathleen, Isaacs Sarah D, Stattin Pär, Xu Jianfeng, Duggan David, Carpten John D, Isaacs William B, Grönberg Henrik, Zheng S Lilly, Chang Bao-Li
Abstract excerpt
We searched for deletions in the germ-line genome among 498 aggressive prostate cancer cases and 494 controls from a population-based study in Sweden [CAncer of the Prostate in Sweden (CAPS)] using Affymetrix SNP arrays. By comparing allele intensities of approximately 500,000 SNP probes across the genome, a germ-line deletion at 2p24.3 was observed to be significantly more common in cases (12.63%) than in...
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