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Article

Tyrosine phosphorylation of Munc18c on residue 521 abrogates binding to Syntaxin 4.

BMC biochemistry - 6 May 2011

Aran Veronica, Bryant Nia J, Gould Gwyn W

Abstract excerpt

BACKGROUND: Insulin stimulates exocytosis of GLUT4 from an intracellular store to the cell surface of fat and muscle cells. Fusion of GLUT4-containing vesicles with the plasma membrane requires the SNARE proteins Syntaxin 4, VAMP2 and the regulatory Sec1/Munc18 protein, Munc18c. Syntaxin 4 and Munc18c form a complex that is disrupted upon insulin treatment of adipocytes. Munc18c is tyrosine phosphorylated in...

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Identifiers

PMID: 21548926
DOI: 10.1186/1471-2091-12-19
PMCID: PMC3103433

Genes

VAMP2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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