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Article

WNK1 is a novel regulator of Munc18c-syntaxin 4 complex formation in soluble NSF attachment protein receptor (SNARE)-mediated vesicle exocytosis.

The Journal of biological chemistry - 9 Nov 2007

Oh Eunjin, Heise Charles J, English Jessie M, Cobb Melanie H, Thurmond Debbie C

Abstract excerpt

Defects in soluble NSF attachment protein receptor (SNARE)-mediated granule exocytosis occur in islet beta cells, adipocytes, and/or skeletal muscle cells correlate with increased susceptibility to insulin resistance and diabetes. The serine/threonine kinase WNK1 (with no K (lysine)) has recently been implicated in exocytosis and is expressed in all three of these cell types. To search for WNK1 substrates related...

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Source

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Identifiers

PMID: 17848561
DOI: 10.1074/jbc.M706591200
PMCID: PMC2423411

Genes

WNK1
NSF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

WNK1 is a novel regulator of Munc18c-syntaxin 4 complex formation in soluble NSF attachment protein receptor (SNARE)-mediated vesicle exocytosis.PMID 17848561Read ↗

Munc18c depletion selectively impairs the sustained phase of insulin release.Semantic proximity Read ↗

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A gain-of-function mutant of Munc18-1 stimulates secretory granule recruitment and exocytosis and reveals a direct interaction of Munc18-1 with Rab3.Semantic proximity Read ↗

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