Article
Renal Cell Carcinoma Programmed Death-ligand 1, a New Direct Target of Hypoxia-inducible Factor-2 Alpha, is Regulated by von Hippel-Lindau Gene Mutation Status.
European urology - 1 Oct 2016
Messai Yosra, Gad Sophie, Noman Muhammad Zaeem, Le Teuff Gwenael, Couve Sophie, Janji Bassam, Kammerer Solenne Florence, Rioux-Leclerc Nathalie, Hasmim Meriem, Ferlicot Sophie, Baud Véronique, Mejean Arnaud, Mole David Robert, Richard Stéphane, Eggermont Alexander M M, Albiges Laurence, Mami-Chouaib Fathia, Escudier Bernard, Chouaib Salem
Abstract excerpt
BACKGROUND: Clear cell renal cell carcinomas (ccRCC) frequently display a loss of function of the von Hippel-Lindau (VHL) gene. OBJECTIVE: To elucidate the putative relationship between VHL mutation status and immune checkpoint ligand programmed death-ligand 1 (PD-L1) expression. DESIGN, SETTING, AND PARTICIPANTS: A series of 32 renal tumors composed of 11 VHL tumor-associated and 21 sporadic RCCs were used to...
Topics
- Alleles
- B7-H1 Antigen
- Basic Helix-Loop-Helix Transcription Factors
- Carcinoma, Renal Cell
- Cell Line, Tumor
- Female
- Gene Expression Regulation, Neoplastic
- Humans