Article
Evidence for insulin-dependent activation of S6 and microtubule-associated protein-2 kinases via a human insulin receptor/v-ros hybrid.
The Journal of biological chemistry - 15 Feb 1990
Boulton T G, Gregory J S, Jong S M, Wang L H, Ellis L, Cobb M H
Abstract excerpt
The abilities of a series of six mutants of the human insulin receptor, an insulin receptor/v-ros hybrid (IR-ros) and the P68gag-ros transforming protein to stimulate S6 protein kinase have been assessed. Insulin receptor mutants in which either 1 or 2 tyrosine residues have been replaced with ph...
Topics
- Animals
- Calcium-Calmodulin-Dependent Protein Kinases
- Cell Line
- Enzyme Activation
- Fusion Proteins, gag-onc
- Insulin
- Kinetics
- Mutation
- Protein Kinases
- Receptor, Insulin
- Ribosomal Protein S6 Kinases
- Transfection