Article
Replacement of the human insulin receptor transmembrane and cytoplasmic domains by corresponding domains of the oncogene product v-ros leads to accelerated internalization, degradation, and down-regulation.
The Journal of biological chemistry - 5 Jun 1990
Berhanu P, Rohilla A M, Rutter W J
Abstract excerpt
Internalization, degradation, and insulin-induced down-regulation of insulin receptors were studied comparatively in transformed Chinese hamster ovary (CHO) cell lines, CHO.T and CHO.IR.ros, respectively expressing either the wild-type human insulin receptor (hIR) or a mutated hybrid receptor in...
Topics
- Affinity Labels
- Animals
- Cell Line
- Cell Membrane
- Chloroquine
- Cricetinae
- Cytoplasm
- Down-Regulation
- Humans
- Insulin
- Kinetics
- Mutation
- Oncogene Proteins, Viral
- Photochemistry
- Receptor Protein-Tyrosine Kinases
- Receptor, Insulin
- Recombinant Fusion Proteins