Article
Immunologic evaluation of spontaneous regression of an intraocular murine melanoma.
Investigative ophthalmology & visual science - 1 Feb 1990
Knisely T L, Niederkorn J Y
Abstract excerpt
The experiments reported here describe the derivation of an immunogenic melanoma cell line from B16 melanoma by sequential in vitro mutagenization with two chemical mutagens: n-methyl n-nitro n-nitrosoguanine (MNNG) and ethane methyl sulfonate (EMS). Following in vivo screening of over 100 mutant melanoma clones, a single clone was selected for further study. When transplanted to the anterior segment of the mouse...
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