Article
Immunologic evaluation of spontaneous regression of an intraocular murine melanoma.
Investigative ophthalmology & visual science - 1 Feb 1990
Knisely T L, Niederkorn J Y
Abstract excerpt
The experiments reported here describe the derivation of an immunogenic melanoma cell line from B16 melanoma by sequential in vitro mutagenization with two chemical mutagens: n-methyl n-nitro n-nitrosoguanine (MNNG) and ethane methyl sulfonate (EMS). Following in vivo screening of over 100 mutant...
Topics
- Animals
- Anterior Eye Segment
- Cell Separation
- Disease Models, Animal
- Eye Neoplasms
- Female
- Flow Cytometry
- Histocompatibility Antigens Class I
- Hypersensitivity, Delayed
- Killer Cells, Natural
- Melanoma, Experimental
- Mesylates
- Methylnitronitrosoguanidine
- Mice
- Mice, Inbred C57BL
- Mutation
- Neoplasm Regression, Spontaneous
- Neoplasm Transplantation