Article
Mutated BRAF Emerges as a Major Effector of Recurrence in a Murine Melanoma Model After Treatment With Immunomodulatory Agents.
Molecular therapy : the journal of the American Society of Gene Therapy - 1 May 2015
Zaidi Shane, Blanchard Miran, Shim Kevin, Ilett Elizabeth, Rajani Karishma, Parrish Christopher, Boisgerault Nicolas, Kottke Tim, Thompson Jill, Celis Esteban, Pulido Jose, Selby Peter, Pandha Hardev, Melcher Alan, Harrington Kevin, Vile Richard
Abstract excerpt
We used a VSV-cDNA library to treat recurrent melanoma, identifying immunogenic antigens, allowing us to target recurrences with immunotherapy or chemotherapy. Primary B16 melanoma tumors were induced to regress by frontline therapy. Mice with recurrent tumors were treated with VSV-cDNA immunotherapy. A Th17 recall response was used to screen the VSV-cDNA library for individual viruses encoding rejection...
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