T Cells Associated with Tumor Regression Recognize Frameshifted Products of the <i>CDKN2A</i> Tumor Suppressor Gene Locus and a Mutated HLA Class I Gene Product

Abstract excerpt

The dramatic tumor regression observed following adoptive T cell transfer in some patients has led to attempts to identify novel Ags to understand the nature of these responses. Nearly complete regression of multiple metastatic melanoma lesions was observed in patient 1913 following adoptive transfer of autologous tumor-infiltrating lymphocytes. The autologous 1913 melanoma cell line expressed a mutated HLA-A11...