Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Tumor escape mutants develop within an immune-privileged environment in the absence of T cell selection.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jul 2006

Chen Peter W, Uno Toshihiko, Ksander Bruce R

Abstract excerpt

The establishment of tumor escape mutants, which can be driven by innate and/or adaptive immune effector cells, presents a significant obstacle in the development of successful tumor immunotherapies. Our study documents that tumors growing within an immune-privileged site within the eye develop a tumor escape phenotype in the absence of selective T cell pressure. P815 tumor cells that are recovered from...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytotoxicity, Immunologic
Share to Eye Neoplasms
Share to H-2 Antigens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Intercellular Adhesion Molecule-1

Share to Leukemia L1210

Share to Lymphocyte Culture Test, Mixed

Share to Mice, Inbred DBA

Share to Tumor Escape

Source

Identifiers

PMID: 16785511
DOI: 10.4049/jimmunol.177.1.162

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tumor escape mutants develop within an immune-privileged environment in the absence of T cell selection.PMID 16785511Read ↗

Adoptive T cell therapy promotes the emergence of genomically altered tumor escape variantsSemantic proximity Read ↗

Tumor evasion may occur via expression of regulatory molecules: a case for CTLA-4 in melanoma.Semantic proximity Read ↗

Immunologic evaluation of spontaneous regression of an intraocular murine melanoma.Semantic proximity Read ↗

Ectopic Expression of Vascular Cell Adhesion Molecule-1 as a New Mechanism for Tumor Immune EvasionSemantic proximity Read ↗

Cellular and Molecular Mechanisms of Anterior Chamber-Associated Immune Deviation (ACAID): What We Have Learned from Knockout MiceSemantic proximity Read ↗

Regulation, counter-regulation, and immunotherapy of autoimmune responses to immunologically privileged retinal antigens.Semantic proximity Read ↗

Tumor-specific CD4(+) suppressor T-cell clone capable of inhibiting rejection of syngeneic sarcoma in A/J mice.Semantic proximity Read ↗

Multiple mechanisms of immune evasion can coexist in melanoma tumor cell lines derived from the same patient.Semantic proximity Read ↗

CTL adoptive immunotherapy concurrently mediates tumor regression and tumor escape.Semantic proximity Read ↗

Direct thymic involvement in anterior chamber-associated immune deviation: evidence for a nondeletional mechanism of centrally induced tolerance to extrathymic antigens in adult mice.Semantic proximity Read ↗

Limited tumor infiltration by activated T effector cells restricts the therapeutic activity of regulatory T cell depletion against established melanoma.Semantic proximity Read ↗

Virus-induced immunoinflammatory lesions in the absence of viral antigen recognition.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.