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Article

Cyclin-dependent kinase inhibitor Cdkn2c regulates B cell homeostasis and function in the NZM2410-derived murine lupus susceptibility locus Sle2c1.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jun 2011

Xu Zhiwei, Potula Hari-Hara S K, Vallurupalli Anusha, Perry Daniel, Baker Henry, Croker Byron P, Dozmorov Igor, Morel Laurence

Abstract excerpt

Sle2c1 is an NZM2410- and NZB-derived lupus susceptibility locus that induces an expansion of the B1a cell compartment. B1a cells have a repertoire enriched for autoreactivity, and an expansion of this B cell subset occurs in several mouse models of lupus. A combination of genetic mapping and candidate gene analysis presents Cdkn2c, a gene encoding for cyclin-dependent kinase inhibitor p18(INK4c) (p18), as the...

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Identifiers

PMID: 21543644
DOI: 10.4049/jimmunol.1002544
PMCID: PMC3774832

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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