Article
A New Zealand Black-derived locus suppresses chronic graft-versus-host disease and autoantibody production through nonlymphoid bone marrow-derived cells.
Journal of immunology (Baltimore, Md. : 1950) - 1 Apr 2011
Xu Zhiwei, Vallurupalli Anusha, Fuhrman Christopher, Ostrov David, Morel Laurence
Abstract excerpt
The development of lupus pathogenesis results from the integration of susceptibility and resistance genes. We have used a chronic graft-versus-host disease (cGVHD) model to characterize a suppressive locus at the telomeric end of the NZM2410-derived Sle2 susceptibility locus, which we named Sle2c2. cGVHD is induced normally in Sle2c2-expressing mice, but it is not sustained. The analysis of mixed bone marrow...
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