Dietary saturated fat, gender and genetic variation at the TCF7L2 locus predict the development of metabolic syndrome.

doi:10.1016/j.jnutbio.2010.11.020

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Article

Dietary saturated fat, gender and genetic variation at the TCF7L2 locus predict the development of metabolic syndrome.

The Journal of nutritional biochemistry - 1 Mar 2012

Phillips Catherine M, Goumidi Louisa, Bertrais Sandrine, Field Martyn R, McManus Ross, Hercberg Serge, Lairon Denis, Planells Richard, Roche Helen M

Abstract excerpt

Transcription factor 7-like 2 (TCF7L2) is the strongest genetic determinant of type 2 diabetes (T2DM) and insulin-related phenotypes to date. Dietary fat is a key environmental factor which may interact with genotype to affect risk of metabolic syndrome (MetS) and T2DM. This study investigated the relationship between the TCF7L2 rs7903146 polymorphism, insulin sensitivity/resistance and MetS in the...

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PMID: 21543200
DOI: 10.1016/j.jnutbio.2010.11.020

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