Article
Gene-nutrient interactions and gender may modulate the association between ApoA1 and ApoB gene polymorphisms and metabolic syndrome risk.
Atherosclerosis - 1 Feb 2011
Phillips Catherine M, Goumidi Louisa, Bertrais Sandrine, Field Martyn R, McManus Ross, Hercberg Serge, Lairon Denis, Planells Richard, Roche Helen M
Abstract excerpt
OBJECTIVE: Dyslipidemia is a key feature of the metabolic syndrome (MetS), which is determined by both genetic and dietary factors. METHODS: We determined the relationships between ApoA1 and ApoB polymorphisms and MetS risk, and whether dietary fat modulates this in the LIPGENE-SU.VI.MAX study of MetS cases and matched controls (n = 1754). RESULTS: ApoB rs512535 and ApoA1 rs670 major G allele homozygotes had...
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