Article
Transactivation of cellular promoters by an integrated hepatitis B virus DNA.
Biochemical and biophysical research communications - 15 Apr 1993
Yamamoto S, Nakatake H, Kawamoto S, Takimoto M, Koshy R, Matsubara K
Abstract excerpt
A new Hepatitis B virus(HBV) DNA integrant clone DA2-6, isolated from a human hepatocellular carcinoma(HCC) genomic library, was tested for its ability to transactivate expression of other genes. DA2-6 consists of 3.7 kb flanking cellular sequences and an integrated 2.8 kb HBV DNA which covers the region of preS, S, and the 3' truncated X. Using a chloramphenicol acetyltransferase (CAT) assay, a number of...
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