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Article

Biosynthetic deficiency of docosahexaenoic acid causes nonalcoholic fatty liver disease and ferroptosis-mediated hepatocyte injury.

The Journal of biological chemistry - 1 Jul 2024

Li Xuehui, Liu Chengjie, Zhang Ru, Li Yi, Ye Ding, Wang Houpeng, He Mudan, Sun Yonghua

Abstract excerpt

Exogenous omega-3 fatty acids, particularly docosahexaenoic acid (DHA), have shown to exert beneficial effects on nonalcoholic fatty liver disease (NAFLD), which is characterized by the excessive accumulation of lipids and chronic injury in the liver. However, the effect of endogenous DHA biosynthesis on the lipid homeostasis of liver is poorly understood. In this study, we used a DHA biosynthesis-deficient...

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Identifiers

PMID: 38788853
DOI: 10.1016/j.jbc.2024.107405
PMCID: PMC11231757

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