Article
Endoplasmic reticulum stress does not contribute to steatohepatitis in obese and insulin-resistant high-fat-diet-fed foz/foz mice.
Clinical science (London, England : 1979) - 1 Oct 2014
Legry Vanessa, Van Rooyen Derrick M, Lambert Barbara, Sempoux Christine, Poekes Laurence, Español-Suñer Regina, Molendi-Coste Olivier, Horsmans Yves, Farrell Geoffrey C, Leclercq Isabelle A
Abstract excerpt
Non-alcoholic fatty liver (steatosis) and steatohepatitis [non-alcoholic steatohepatitis (NASH)] are hepatic complications of the metabolic syndrome. Endoplasmic reticulum (ER) stress is proposed as a crucial disease mechanism in obese and insulin-resistant animals (such as ob/ob mice) with simpl...
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