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Article

Thymidylate synthase expression and genotype have no major impact on the clinical outcome of colorectal cancer patients treated with 5-fluorouracil.

Pharmacological research - 1 Sept 2011

Vignoli Marina, Nobili Stefania, Napoli Cristina, Putignano Anna Laura, Morganti Maria, Papi Laura, Valanzano Rosa, Cianchi Fabio, Tonelli Francesco, Mazzei Teresita, Mini Enrico, Genuardi Maurizio

Abstract excerpt

BACKGROUND AND OBJECTIVES: Thymidylate synthase (TS) expression levels appear to be related to response to 5-fluorouracil-(5-FU)-based chemotherapy in colorectal cancer (CRC) patients. Three polymorphisms have been proposed as modulators of TS expression: a tandemly repeated sequence (2R/3R) in the 5' UTR, a SNP (G>C) within the 3R allele and a 6bp deletion in the 3' UTR. To evaluate the influence of TS...

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Identifiers

PMID: 21536130
DOI: 10.1016/j.phrs.2011.04.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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