Article
Relationship between thymidylate synthase (TS) genotype and TS expression: a tissue microarray analysis of colorectal cancers.
International journal of surgical pathology - 1 Apr 2005
Popat Sanjay, Wort Richard, Houlston Richard S
Abstract excerpt
Response of colorectal cancers to 5-fluorouracil appears to be influenced by differences in thymidylate synthase (TS) expression. To explore the relationship between TS 5' genotype and expression, we analyzed paired tumor and normal tissue from 87 colorectal cancers by tissue microarray. A trend to an association between TS genotype and expression was observed, but the correlation was weak. Although the 2R...
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