Article
Thymidylate synthase polymorphisms and mRNA expression are independent chemotherapy predictive markers in esophageal adenocarcinoma patients.
International journal of oncology - 1 Jan 2008
Kuramochi Hidekazu, Tanaka Koji, Oh Daniel, Lehman Bethany J, Dunst Christy M, Yang Dong Yun, De Meester Steven R, Hagen Jeffery A, Danenberg Kathleen D, De Meester Tom R, Danenberg Peter V
Abstract excerpt
Thymidylate synthase (TS) is known to have polymorphisms in the 5' and 3' untranslated region (UTR). These polymorphisms have been reported to be associated with high TS expression and chemoresistance to 5-FU. The aim of this study was to examine the prognostic roles of the 5'-UTR and 3'-UTR TS polymorphisms in esophageal adenocarcinoma patients, as well as their relation with TS mRNA expression. Eighty-three...
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