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Article

Different requirements for σ Region 4 in BvgA activation of the Bordetella pertussis promoters P(fim3) and P(fhaB).

Journal of molecular biology - 24 Jun 2011

Decker Kimberly B, Chen Qing, Hsieh Meng-Lun, Boucher Philip, Stibitz Scott, Hinton Deborah M

Abstract excerpt

Bordetella pertussis BvgA is a global response regulator that activates virulence genes, including adhesin-encoding fim3 and fhaB. At the fhaB promoter, P(fhaB), a BvgA binding site lies immediately upstream of the -35 promoter element recognized by Region 4 of the σ subunit of RNA polymerase (RNAP). We demonstrate that σ Region 4 is required for BvgA activation of P(fhaB), a hallmark of Class II activation. In...

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Identifiers

PMID: 21536048
DOI: 10.1016/j.jmb.2011.04.017
PMCID: PMC3141349

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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