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Article

The BvgAS Regulon of Bordetella pertussis

10 Oct 2017

Abstract excerpt

ABSTRACT Nearly all virulence factors in Bordetella pertussis are activated by a master two-component system, BvgAS, composed of the sensor kinase BvgS and the response regulator BvgA. When BvgS is active, BvgA is phosphorylated (BvgA~P), and virulence-activated genes ( vag s) are expressed [Bvg(+) mode]. When BvgS is inactive and BvgA is not phosphorylated, virulence-repressed genes ( vrg s) are induced [Bvg(−)...

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Identifiers

PMID: 29018122
DOI: 10.1128/mbio.01526-17

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