The proline residue at position 319 of BvgS is essential for BvgAS activation in Bordetella pertussis.

doi:10.1093/femspd/ftx011

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Article

The proline residue at position 319 of BvgS is essential for BvgAS activation in Bordetella pertussis.

Pathogens and disease - 1 Jan 2017

Hiramatsu Yukihiro, Yoshino Shuji, Yamamura Yoshiko, Otsuka Nao, Shibayama Keigo, Watanabe Mineo, Kamachi Kazunari

Abstract excerpt

Bordetella pertussis is the etiological agent of pertussis and produces various virulence factors, including pertussis toxin (PT), filamentous hemagglutinin (FHA) and pertactin (PRN), most of which are positively regulated by the BvgAS two-component sensory transduction system. Here, we describe a B. pertussis isolate not expressing PT, FHA and PRN recovered from a pertussis patient. Sequencing revealed that the...

Topics

Amino Acid Substitution
Bacterial Proteins
Bordetella pertussis
Codon
Gene Expression Regulation, Bacterial
Humans
Mutation
Proline
Transcription Factors
Virulence

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Open in PubMed

Identifiers

PMID: 28158456
DOI: 10.1093/femspd/ftx011

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