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Article

A vir-repressed gene of Bordetella pertussis is required for virulence.

Infection and immunity - 1 Feb 1992

Beattie D T, Shahin R, Mekalanos J J

Abstract excerpt

Coordinate regulation of gene expression in Bordetella pertussis is controlled by the products of the vir locus, BvgA and BvgS. In the presence of modulating signals such as MgSO4 and nicotinic acid, expression of vir-activated genes (vag) is reduced, while expression of vir-repressed genes (vrg) is maximal. We have cloned one of these vir-repressed genes, vrg-6, in Escherichia coli. DNA sequencing has shown that...

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Identifiers

PMID: 1730491
DOI: 10.1128/iai.60.2.571-577.1992
PMCID: PMC257666

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A vir-repressed gene of Bordetella pertussis is required for virulence.PMID 1730491Read ↗

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