A vir-repressed gene of Bordetella pertussis is required for virulence.

doi:10.1128/iai.60.2.571-577.1992

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Article

A vir-repressed gene of Bordetella pertussis is required for virulence.

Infection and immunity - 1 Feb 1992

Beattie D T, Shahin R, Mekalanos J J

Abstract excerpt

Coordinate regulation of gene expression in Bordetella pertussis is controlled by the products of the vir locus, BvgA and BvgS. In the presence of modulating signals such as MgSO4 and nicotinic acid, expression of vir-activated genes (vag) is reduced, while expression of vir-repressed genes (vrg)...

Topics

Amino Acid Sequence
Base Sequence
Bordetella pertussis
Cloning, Molecular
Gene Expression
Genes, Bacterial
Molecular Sequence Data
Mutation
Virulence

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