Temperature-sensitive mutants for steroid-sensitive growth of S115 mouse mammary tumor cells.

doi:10.1016/0014-4827(90)90308-w

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Article

Temperature-sensitive mutants for steroid-sensitive growth of S115 mouse mammary tumor cells.

Experimental cell research - 1 Feb 1990

Härkönen P L, Laaksonen E I, Valve E M, Solic N, Darbre P D

Abstract excerpt

We have generated temperature-sensitive (ts) mutants for steroid-regulated anchorage-independent cell growth. Androgen-responsive S115+A mouse mammary tumor cells were mutagenized with ethyl methane sulfonate and the variants which were growth-arrested in suspension at the nonpermissive temperature of 41 degrees C were selected by killing dividing wild-type cells with the DNA synthesis inhibitors...

Topics

Androgens
Animals
Blood
Cell Division
Chloramphenicol O-Acetyltransferase
Cloning, Molecular
Cytarabine
Ethyl Methanesulfonate
Floxuridine
Gammaretrovirus
Gene Expression

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Kinetics

Mammary Neoplasms, Experimental

Mice

Mutation

RNA, Viral

Receptors, Androgen

Temperature

Source

Open in PubMed

Identifiers

PMID: 2153558
DOI: 10.1016/0014-4827(90)90308-w

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2153558-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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