Article
Genetic variants associated with Von Willebrand factor levels in healthy men and women identified using the HumanCVD BeadChip.
Annals of human genetics - 1 Jul 2011
Zabaneh Delilah, Gaunt Tom R, Kumari Meena, Drenos Fotios, Shah Sonia, Berry Diane, Power Chris, Hypponen Elina, Shah Tina, Palmen Jutta, Pallas Jacky, Talmud Philippa J, Casas Juan Pablo, Sofat Reecha, Lowe Gordon, Rumley Ann, Morris Richard W, Whincup Peter H, Rodriguez Santiago, Ebrahim Shah, Marmot Michael G, Smith George Davey, Lawlor Debbie A, Kivimaki Mika, Whittaker John, Hingorani Aroon D, Day Ian N, Humphries Steve E
Abstract excerpt
We have used the gene-centric Illumina HumanCVD BeadChip to identify common genetic determinants of Von Willebrand factor (vWF) levels in healthy men and women. The Whitehall II (WHII) study (n= 5592) and the British Women's Heart and Health Study (BWHHS) (n= 3445) were genotyped using the HumanCVD BeadChip. Replication was conducted in the British Regional Heart Study (n= 3897) and 1958 Birth Cohort (n= 5048)....
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