Linkage analysis identifies a locus for plasma von Willebrand factor undetected by genome-wide association.

doi:10.1073/pnas.1219885110

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Article

Linkage analysis identifies a locus for plasma von Willebrand factor undetected by genome-wide association.

Proceedings of the National Academy of Sciences of the United States of America - 8 Jan 2013

Desch Karl C, Ozel Ayse B, Siemieniak David, Kalish Yossi, Shavit Jordan A, Thornburg Courtney D, Sharathkumar Anjali A, McHugh Caitlin P, Laurie Cathy C, Crenshaw Andrew, Mirel Daniel B, Kim Yoonhee, Cropp Cheryl D, Molloy Anne M, Kirke Peadar N, Bailey-Wilson Joan E, Wilson Alexander F, Mills James L, Scott John M, Brody Lawrence C, Li Jun Z, Ginsburg David

Abstract excerpt

The plasma glycoprotein von Willebrand factor (VWF) exhibits fivefold antigen level variation across the normal human population determined by both genetic and environmental factors. Low levels of VWF are associated with bleeding and elevated levels with increased risk for thrombosis, myocardial infarction, and stroke. To identify additional genetic determinants of VWF antigen levels and to minimize the impact of...

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PMID: 23267103
DOI: 10.1073/pnas.1219885110
PMCID: PMC3545809

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Linkage analysis identifies a locus for plasma von Willebrand factor undetected by genome-wide association.PMID 23267103Read ↗

Genome-wide association studies identify genetic loci for low von Willebrand factor levels.Semantic proximity Read ↗

Genetic determinants of plasma von Willebrand factor antigen levels: a target gene SNP and haplotype analysis of ARIC cohort.Semantic proximity Read ↗

Genome-wide linkage analysis of von Willebrand factor plasma levels: results from the GAIT projectSemantic proximity Read ↗

Genetic study of von Willebrand factor antigen levels ≤ 50 IU/dL identifies variants associated with increased risk of von Willebrand disease and bleeding.Semantic proximity Read ↗

Genome-wide studies of von Willebrand factor propeptide identify loci contributing to variation in propeptide levels and von Willebrand factor clearance.Semantic proximity Read ↗

Genetic variants associated with Von Willebrand factor levels in healthy men and women identified using the HumanCVD BeadChip.Semantic proximity Read ↗

Population-based prevalence and mutational landscape of von Willebrand disease using large-scale genetic databasesSemantic proximity Read ↗

Unravelling the spectrum of von Willebrand factor variants in quantitative von Willebrand disease: results from a German cohort study.Semantic proximity Read ↗

Updated global prevalence and ethnic diversity of von Willebrand disease based on population genetics analysisSemantic proximity Read ↗

Novel associations of multiple genetic loci with plasma levels of factor VII, factor VIII, and von Willebrand factor: The CHARGE (Cohorts for Heart and Aging Research in Genome Epidemiology) Consortium.Semantic proximity Read ↗

Population-based prevalence and mutational landscape of von Willebrand disease using large-scale genetic databasesSemantic proximity Read ↗

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