Article
Genome-wide association studies identify genetic loci for low von Willebrand factor levels.
European journal of human genetics : EJHG - 1 Jul 2016
van Loon Janine, Dehghan Abbas, Weihong Tang, Trompet Stella, McArdle Wendy L, Asselbergs Folkert W, Chen Ming-Huei, Lopez Lorna M, Huffman Jennifer E, Leebeek Frank W G, Basu Saonli, Stott David J, Rumley Ann, Gansevoort Ron T, Davies Gail, Wilson James J F, Witteman Jacqueline C M, Cao Xiting, de Craen Anton J M, Bakker Stephan J L, Psaty Bruce M, Starr John M, Hofman Albert, Wouter Jukema J, Deary Ian J, Hayward Caroline, van der Harst Pim, Lowe Gordon D O, Folsom Aaron R, Strachan David P, Smith Nicolas, de Maat Moniek P M, O'Donnell Christopher
Abstract excerpt
Low von Willebrand factor (VWF) levels are associated with bleeding symptoms and are a diagnostic criterion for von Willebrand disease, the most common inherited bleeding disorder. To date, it is unclear which genetic loci are associated with reduced VWF levels. Therefore, we conducted a meta-analysis of genome-wide association studies to identify genetic loci associated with low VWF levels. For this...
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