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Article

Structure-based affinity maturation of a chimeric anti-ricin antibody C4C13.

Journal of biomolecular structure & dynamics - 1 Jan 2014

Luo Longlong, Luo Qun, Guo Leiming, Lv Ming, Lin Zhou, Geng Jing, Li Xinying, Li Yan, Shen Beifen, Qiao Chunxia, Feng Jiannan

Abstract excerpt

Ricin is a highly lethal toxin. Anti-ricin chimeric monoclonal antibody (mAb) C4C13 was prepared in our lab; however, its binding affinity was much weaker than that of the parent antibody 4C13. In this study, based on the computer-guided homology modeling and conformational optimization methods, the 3-D structure of C4C13 variable regions Fv was constructed and optimized. Using molecular docking and dynamics...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23527922
DOI: 10.1080/07391102.2013.771380

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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