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Article

Induction by interleukin-2 of oligoclonal expansion of cultured tumor-infiltrating lymphocytes.

Journal of the National Cancer Institute - 17 Jan 1990

Fishleder A J, Finke J H, Tubbs R, Bukowski R M

Abstract excerpt

To better understand the modulatory effects of interleukin-2 (IL-2) on lymphocyte proliferation, we examined the clonality of the in vitro T-cell response by Southern blot hybridization. Tumor-infiltrating lymphocytes (TILs) grown in the presence of IL-2 for 15-26 days had detectable T-cell receptor beta-chain gene rearrangements, which indicated oligoclonal enhancement in culture in four of nine TIL samples. In...

Topics

Blotting, Southern
Carcinoma, Renal Cell
Cell Separation
Cells, Cultured
Clone Cells
DNA, Neoplasm
Flow Cytometry
Gene Rearrangement, beta-Chain T-Cell Antigen Receptor
Humans
Interleukin-2
Kidney Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Leukocyte Count

Phenotype

T-Lymphocytes

Source

Identifiers

PMID: 2152945
DOI: 10.1093/jnci/82.2.124

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2152945-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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