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Article

Induction by interleukin-2 of oligoclonal expansion of cultured tumor-infiltrating lymphocytes.

Journal of the National Cancer Institute - 17 Jan 1990

Fishleder A J, Finke J H, Tubbs R, Bukowski R M

Abstract excerpt

To better understand the modulatory effects of interleukin-2 (IL-2) on lymphocyte proliferation, we examined the clonality of the in vitro T-cell response by Southern blot hybridization. Tumor-infiltrating lymphocytes (TILs) grown in the presence of IL-2 for 15-26 days had detectable T-cell receptor beta-chain gene rearrangements, which indicated oligoclonal enhancement in culture in four of nine TIL samples. In...

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Source

Identifiers

PMID: 2152945
DOI: 10.1093/jnci/82.2.124

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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