Article
Enhanced interleukin-2 production in human tumor-infiltrating lymphocytes engineered by 3'-truncated interleukin-2 gene.
Journal of immunotherapy with emphasis on tumor immunology : official journal of the Society for Biological Therapy - 1 Nov 1994
Yamaue H, Kashmiri S V, De Filippi R, Nieroda C, Yannelli J R, Tsang K Y, Schlom J
Abstract excerpt
Tumor-infiltrating lymphocytes (TILs), T lymphocytes associated with solid tumors that can be grown with interleukin (IL)-2 in vitro, preferentially accumulate at tumor sites after adoptive transfer. Therefore, TILs can be considered for use as cellular vehicles in gene therapy. We transduced mel...
Topics
- Base Sequence
- Cell Division
- Cytotoxicity, Immunologic
- Drug Resistance, Microbial
- Flow Cytometry
- Humans
- Interleukin-2
- Lymphocytes, Tumor-Infiltrating
- Melanoma
- Molecular Sequence Data
- Phenotype
- Time Factors
- Transduction, Genetic
- Tumor Cells, Cultured