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Article

Genome delivery and ion channel properties are altered in VP4 mutants of poliovirus.

Journal of virology - 1 May 2003

Danthi Pranav, Tosteson Magdalena, Li Qi-Han, Chow Marie

Abstract excerpt

During entry into host cells, poliovirus undergoes a receptor-mediated conformational transition to form 135S particles with irreversible exposure of VP4 capsid sequences and VP1 N termini. To understand the role of VP4 during virus entry, the fate of VP4 during infection by site-specific mutants at threonine-28 of VP4 (4028T) was compared with that of the parental Mahoney type 1 virus. Three virus mutants were...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 12692228
DOI: 10.1128/jvi.77.9.5266-5274.2003
PMCID: PMC153979

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Source receipt: pubmed, retrieved 7 Sept 2026.

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