Genome delivery and ion channel properties are altered in VP4 mutants of poliovirus.

doi:10.1128/jvi.77.9.5266-5274.2003

Back to search

Article

Genome delivery and ion channel properties are altered in VP4 mutants of poliovirus.

Journal of virology - 1 May 2003

Danthi Pranav, Tosteson Magdalena, Li Qi-Han, Chow Marie

Abstract excerpt

During entry into host cells, poliovirus undergoes a receptor-mediated conformational transition to form 135S particles with irreversible exposure of VP4 capsid sequences and VP1 N termini. To understand the role of VP4 during virus entry, the fate of VP4 during infection by site-specific mutants...

Topics

Capsid Proteins
Cell Membrane
Genome, Viral
HeLa Cells
Humans
Ion Channels
Mutation
Poliovirus
RNA, Viral
Virion
Virus Assembly

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.