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Article

Paraoxonase-1 is not a major determinant of stent thrombosis in a Taiwanese population.

PloS one - 1 Jan 2012

Chen Dong-Yi, Wang Chao-Yung, Wen Ming-Shien, Lee Tsong-Hai, Chu Yen, Hsieh Ming-Jer, Chang Shang-Hung, Lee Cheng-Hung, Wang Jian-Liang, Chen Chun-Chi, Lu Laing-Suei, Lee Ming-Ta, Yeh San-Jou, Lin Fun-Chiung, Hsieh I-Chang

Abstract excerpt

BACKGROUND: Clopidogrel is a prodrug that undergoes in vivo bioactivation to show its antiplatelet effects. Recent studies have shown that cytochrome P450 (CYP), ATP-binding cassette transporters (ABCB1), and paraoxonase-1 (PON1) play crucial roles in clopidogrel bioactivation. Here, we aim to determine the effects of genetic polymorphisms of CYP (CYP 2C19*2, CYP 2C19*3, and CYP 2C19*17), ABCB1 (ABCB1 3435C>T,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to ATP Binding Cassette Transporter, Subfamily B

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Source

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Identifiers

PMID: 22723959
DOI: 10.1371/journal.pone.0039178
PMCID: PMC3377663

Genes

PON1
ABCB1

Variants

Provenance

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