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Article

The HARP domain dictates the annealing helicase activity of HARP/SMARCAL1.

EMBO reports - 1 Jun 2011

Ghosal Gargi, Yuan Jingsong, Chen Junjie

Abstract excerpt

Mutations in HepA-related protein (HARP, or SMARCAL1) cause Schimke immunoosseous dysplasia (SIOD). HARP has ATP-dependent annealing helicase activity, which helps to stabilize stalled replication forks and facilitate DNA repair during replication. Here, we show that the conserved tandem HARP (2HP) domain dictates this annealing helicase activity. Furthermore, chimeric proteins generated by fusing the 2HP domain...

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Identifiers

PMID: 21525954
DOI: 10.1038/embor.2011.74
PMCID: PMC3128281

Genes

SMARCAL1
HELLS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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