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Article

Ligand-induced conformation changes drive ATP hydrolysis and function in SMARCAL1.

The FEBS journal - 1 Oct 2015

Gupta Meghna, Mazumder Mohit, Dhatchinamoorthy Karthik, Nongkhlaw Macmillan, Haokip Dominic Thangminlen, Gourinath Samudrala, Komath Sneha Sudha, Muthuswami Rohini

Abstract excerpt

Mutations and deletions in SMARCAL1, an SWI2/SNF2 protein, cause Schimke immuno-osseous dysplasia (SIOD). SMARCAL1 preferentially binds to DNA molecules possessing double-stranded to single-stranded transition regions and mediates annealing helicase activity. The protein is critical for alleviating replication stress and maintaining genome integrity. In this study, we have analysed the ATPase activity of three...

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Source

Identifiers

PMID: 26195148
DOI: 10.1111/febs.13382

Genes

SMARCAL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Ligand-induced conformation changes drive ATP hydrolysis and function in SMARCAL1.PMID 26195148Read ↗

SMARCAL1, the annealing helicase and the transcriptional co-regulator.Semantic proximity Read ↗

Identification of SMARCAL1 as a component of the DNA damage response.Semantic proximity Read ↗

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The annealing helicase SMARCAL1 maintains genome integrity at stalled replication forks.Semantic proximity Read ↗

SMARCB1 missense mutants disrupt SWI/SNF complex stability and remodeling activitySemantic proximity Read ↗

The SWI/SNF Subunit INI1 Contains an N-Terminal Winged Helix DNA Binding Domain that Is a Target for Mutations in Schwannomatosis.Semantic proximity Read ↗

SMARCAL1: a DNA repair protein recruited to double-strand breaks at stalled replication forks to promote genome stability through a homologous recombination pathwaySemantic proximity Read ↗

Novel SMARCAL1 bi-allelic mutations associated with a chromosomal breakage phenotype in a severe SIOD patient.Semantic proximity Read ↗

Gene of the month: <i>SMARCB1</i>Semantic proximity Read ↗

Mutant chromatin remodeling protein SMARCAL1 causes Schimke immuno-osseous dysplasia.Semantic proximity Read ↗

Penetrance of biallelic SMARCAL1 mutations is associated with environmental and genetic disturbances of gene expression.Semantic proximity Read ↗

Recurrent SMARCB1 Mutations Reveal a Nucleosome Acidic Patch Interaction Site That Potentiates mSWI/SNF Complex Chromatin Remodeling.Semantic proximity Read ↗

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