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Dopamine transporter gene variant affecting expression in human brain is associated with bipolar disorder.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Jul 2011

Pinsonneault Julia K, Han Dawn D, Burdick Katherine E, Kataki Maria, Bertolino Alessandro, Malhotra Anil K, Gu Howard H, Sadee Wolfgang

Abstract excerpt

The gene encoding the dopamine transporter (DAT) has been implicated in CNS disorders, but the responsible polymorphisms remain uncertain. To search for regulatory polymorphisms, we measured allelic DAT mRNA expression in substantia nigra of human autopsy brain tissues, using two marker SNPs (rs6347 in exon 9 and rs27072 in the 3'-UTR). Allelic mRNA expression imbalance (AEI), an indicator of cis-acting...

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PMID: 21525861
DOI: 10.1038/npp.2011.45
PMCID: PMC3138671

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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