Fine-mapping reveals novel alternative splicing of the dopamine transporter.

doi:10.1002/ajmg.b.31125

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Article

Fine-mapping reveals novel alternative splicing of the dopamine transporter.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Dec 2010

Talkowski Michael E, McCann Kathleen L, Chen Michael, McClain Lora, Bamne Mikhil, Wood Joel, Chowdari Kodavali V, Watson Annie, Prasad Konasale M, Kirov George, Georgieva Lyudmilla, Toncheva Draga, Mansour Hader, Lewis David A, Owen Michael, O'Donovan Michael, Papasaikas Panagiotis, Sullivan Patrick, Ruderfer Douglas, Yao Jeffrey K, Leonard Sherry, Thomas Pramod, Miyajima Fabio, Quinn John, Lopez A Javier, Nimgaonkar Vishwajit L

Abstract excerpt

The dopamine transporter gene (SLC6A3, DAT) has been implicated in the pathogenesis of numerous psychiatric and neurodevelopmental disorders, including schizophrenia (SZ). We previously detected association between SZ and intronic SLC6A3 variants that replicated in two independent Caucasian samples, but had no obvious function. In follow-up analyses, we sequenced the coding and intronic regions of SLC6A3 to...

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PMID: 20957647
DOI: 10.1002/ajmg.b.31125
PMCID: PMC4575812

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