Article
Temporal variations in the hepatitis C virus intrahost population during chronic infection.
Journal of virology - 1 Jul 2011
Ramachandran Sumathi, Campo David S, Dimitrova Zoya E, Xia Guo-liang, Purdy Michael A, Khudyakov Yury E
Abstract excerpt
The intrahost evolution of hepatitis C virus (HCV) holds keys to understanding mechanisms responsible for the establishment of chronic infections and to development of a vaccine and therapeutics. In this study, intrahost variants of two variable HCV genomic regions, HVR1 and NS5A, were sequenced from four treatment-naïve chronically infected patients who were followed up from the acute stage of infection for 9 to...
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